Niu et al. found that aldolase A was induced by hypoxia‐inducible factor α and epigenetic modifications to overcome hypoxia in HCC cells.[33] Another study suggested that adenylosuccinate lyase (ADSL) is the key enzyme involved in purine metabolism and mitochondrial function during the formation of liver cancer.[34] Liver cancer cells like many other cancer cells are addicted to glutamine. Here, ADSL is linked to hepatocellular carcinoma.