As over 90% glucose is converted into lactic acid through aerobic glycolysis, glutamine becomes the main source of carbon and nitrogen for anabolic processes to support cancer growth.[4] Glutamine is catabolized into glutamate by glutaminase (GLS) and glutamate is further converted into α‐ketoglutarate (α‐KG) by glutamate dehydrogenase (GLUD). This evidence concerns the gene GLS and cancer.