The addition of soluble form of α‐KG (Dimethyl‐α‐ketoglutarate, DMKG [4 mm]) could restore the viability of PDHA, PDHB and PC KO clones under glutamine depletion (GLN−, 0 mm) (Figure 2E), suggesting that the effects of glutamine and pyruvate metabolism inhibition on HCC are at least partially caused by α‐KG. The gene discussed is PDHA1; the disease is hepatocellular carcinoma.