Caloric restriction or low glycemic diet has been shown to be able to repress pancreatic cancer growth through repressing stearoyl‐CoA desaturase (SCD), leading to reduction of monosaturated fatty acids.[29] Dietary methionine restriction also repressed colorectal cancer through modulating the metabolites in one carbon metabolism which supports antioxidant and nucleotide synthesis. Here, SCD is linked to colorectal cancer.