The expression of ERS-related proteins GRP78, CHOP, IRE1α, XBP-1s, cleaved-caspase-12 and cleaved caspase 4 were also significantly increased in normal cells and cancer cells when treated by 0.1 mg/ml and 1 mg/ml pepsin (Figure 3A and 3B). The gene discussed is CASP12; the disease is cancer.