Although some of immunotherapy agents like depatuxizumab [3] manifested curing effects in recurrent glioblastoma patients, other agents including bevacizumab [4, 5] and PD-1/PD-L1 antibodies such as nivolumab [6, 7] and the like, which have been proven effective for the treatment of other tumors, are of limited value for primary glioma patients. This evidence concerns the gene CD274 and central nervous system cancer.