Although there was a significant weight loss in this study (range, -44.9 kg to + 11.6 kg), after 12 months, included women had a mean BMI of 33.8 ±4.0 kg (PCOS) 35.1± 5.4 kg (non-PCOS) and were still classified as having obesity or severe obesity, which is associated with IR and ovulatory dysfunction, and possibly, therefore, we could not find decreased levels of circulating AMH. This evidence concerns the gene AMH and obesity due to melanocortin 4 receptor deficiency.