The study by Thompson et al. [56] in U.S. on cancer screening with 2950 men over 50 years old showed that 15.2% of patients had PSA < 4 ng/mL got prostate cancer, as well as 14.9% of the negative prediction group with a Gleason score of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\ge$$\end{document}7 [56]. The gene discussed is KLK3; the disease is Familial prostate cancer.