We find the spliceosome enriched within BA4 ALS synapses, and it would be important to unravel what effect this may have on the splicing and subsequent composition of synaptic proteins, especially given recent data linking TDP-43 mislocalisation to aberrant splicing and decreased expression of the synaptic protein Munc13-1 (UNC13A) [63, 64]. This evidence concerns the gene UNC13A and amyotrophic lateral sclerosis.