The pathological mechanisms of vascular calcification in the population with CKD are complex and involve traditional risk factors, including sex, age, smoking history, hypertension, diabetes, and hyperlipidemia, as well as risk factors unique to patients with CKD, such as kidney function decline, elevated parathyroid hormone (PTH) level, inflammation, oxidative stress, and mineral and bone disorders [6]. The gene discussed is PTH; the disease is bone disorder.