And when using the threshold of ALT increased more than 10% of ULN (ALT change > 3 U/L) for the definition of ALT elevation, ADG use and patients with NAFLD who gained weight were independently associated with having ALT elevation with an adjusted OR of 1.62 (95%CI 1.02–2.57, p = 0.042) and 2.37 (95%CI 1.01–5.54, p = 0.046), respectively. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.