Since, SPNS2 was a transitive protein and not the primary interactor of target genes, its expression was analysed only in the TCGA cohort and was correlated with SPHK1. It was observed that the SPNS2 levels were downregulated in tumor tissue as compared to adjacent normal tissue (***p < 0.0001) (Fig. 11A). This evidence concerns the gene SPNS2 and neoplasm.