Compared with the Ctrl IIM and HD groups, the frequencies of ISG15+ and MX1+ B cells, CD4+ and CD8+ T cells were noticeably higher in the MDA5+ DM-Act group (Fig. 7b),and these frequencies were decreased in the MDA5+ DM-Rem group (Supplementary Fig. 7c). The gene discussed is ISG15; the disease is Huntington disease.