NLRP3 and Decreased total leukocyte count: We found that the DC patient exhibited immunological features of defective NLRP3 inflammasomes in monocytes, immature NK dominance with fewer cytotoxic NK cells (CD56dim NK cells), and defective B-cell activation or maturation, suggesting that the causes of poor immune responses in the DC patient are caused by not only leukopenia but also dysfunction of immune cells.