ERBB2 and breast cancer: High and low expression of LINC00589 were determined by ISH as represented in Fig. 1D. The results suggest that there is no obvious correlation between LINC00589 expression and age, menopausal status, histologic grade, lymph node status, ER status or PR status in HER2-positive breast cancer patient tissues; however, LINC00589 expression was significantly correlated with TNM stage (Table 1).