Given that CD4+ T cells were critical for the survival benefit in CaMKK2-deficient mice and that these mice demonstrated increased intratumoral accumulation of an effector CD4+ phenotype (associated with ICB response), we suspect that CD4+ TILs additionally strongly contribute to the overall anti-tumor effect and ICB response in the CaMKK2 KO TME. Here, CD4 is linked to neoplasm.