The increased abundance of IFNγ secreting CD4+ TILs in CaMKK2-deficient mice, in addition to chemotactic signals from DC-like TAMs (Cxcl9, Cxcl10), may explain the enhanced tumor penetrance seen by CD4+ and myeloid cells in the setting of CaMKK2 deficiency. This evidence concerns the gene CAMKK2 and neoplasm.