And according to the prominent kinase-phosphosite pathway profile, we summarized the data from the PRM and 4D-LFQ, MAP3Ks, and MAP2Ks are associated with increased phosphorylation of VCL, LCP1, TGFB1I1, and VAPB, indicating the MAPK pathway can affect cell adhesion and cell migration, which also provides a potential new regulatory mechanism for SLE pathogenesis study. The gene discussed is VAPB; the disease is systemic lupus erythematosus.