CD226 and rheumatoid arthritis: Seven phosphosites (BIN2 S458, CD226 S290, TLN1 S1201, plastin-2 [LCP1] S5, adenylyl cyclase-associated protein 1 [CAP1] S308, VCL S275 and VCL S579) were upregulated, and one phosphosite was downregulated (TGFB1I1 S68) in the SLE_S and SLE_A groups compared with the HC group, and among these phosphosites, CD226 S290, VCL S275, and VCL S579 showed higher expression in the SLE_S and SLE_A groups than in the RA group (Fig. 6B).