Although this variant does not cause hyperactivation of NLRP1 per se, as autoproteolysis itself is required but not sufficient for NLRP1 inflammasome activation (28), it has been associated with an increased risk of developing several autoimmune syndromes such as asthma or Crohn's disease (28, 29, 30, 31). This evidence concerns the gene NLRP1 and asthma.