Many studies with a focus on genetic risk factors in human NLRP1 describe SNP rs11651270, causing the missense mutation M1184V, to have dichotomous effects on the development of a multitude of autoimmune syndromes like asthma, inflammatory bowel disease, malignant melanoma, or diabetes (28, 31, 33, 34). Here, NLRP1 is linked to melanoma.