Since c-FLIP binds to FADD via the death-effector domains, preventing precursor of caspase-8 from binding to FADD and causing death receptor-mediated apoptotic cascade to break [4], several chemical compounds could make cancer cell lines sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by targeting c-FLIP protein for proteasome-dependent degradation [7–13]. Here, CFLAR is linked to cancer.