Moreover, we performed tumor tissue- and cell-level GSEA to determine the possible molecular mechanisms by which CXCR4 manifests its effects in NSCLC and found that MYC targets, DNA repair, and inflammation are associated with CXCR4 expression in LUAD, while the Notch signaling pathway and epithelial–mesenchymal transition are associated with CXCR4 expression in LUSC. This evidence concerns the gene CXCR4 and neoplasm.