Model construction of 20 succinylation modification‐related genes could be reliable in predicting prognosis in HCC (MEAF6, OXCT1, SIRT2, CREBBP, KAT5, SIRT4, SIRT6, SIRT7, CPT1A, GLYATL1, SDHA, SDHB, SDHC, SDHD, SIRT1, SIRT3, SIRT5, SUCLA2, SUCLG1 and SUCLG2). This evidence concerns the gene SIRT6 and hepatocellular carcinoma.