Model construction of 20 succinylation modification‐related genes could be reliable in predicting prognosis in HCC (MEAF6, OXCT1, SIRT2, CREBBP, KAT5, SIRT4, SIRT6, SIRT7, CPT1A, GLYATL1, SDHA, SDHB, SDHC, SDHD, SIRT1, SIRT3, SIRT5, SUCLA2, SUCLG1 and SUCLG2). The gene discussed is SIRT2; the disease is hepatocellular carcinoma.