Model construction of 20 succinylation modification‐related genes could be reliable in predicting prognosis in HCC (MEAF6, OXCT1, SIRT2, CREBBP, KAT5, SIRT4, SIRT6, SIRT7, CPT1A, GLYATL1, SDHA, SDHB, SDHC, SDHD, SIRT1, SIRT3, SIRT5, SUCLA2, SUCLG1 and SUCLG2). Here, CREBBP is linked to hepatocellular carcinoma.