STAT3 and Other metabolic disease: 2018). Ectopic expression of STAT3 in the liver increases the circulating lipids in metabolic diseases by altering the expression of liver genes involved in hepatic lipid metabolism (Richard and Stephens 2011). JAK2/STAT3 activity was significantly increased in the livers of NASH mice, which contributed to the progression of steatosis (Zhu, Zhou et al. 2018).