Thus, SIAH1 not only promotes the ubiquitination of other PD proteins, including α‐synuclein and LRRK2 (Rott et al., 2008; Shani et al., 2019) but now also represents a ubiquitin ligase that promotes degradation of PINK1, most likely in the course of its translocation to mitochondria. This evidence concerns the gene LRRK2 and Parkinson disease.