It has been reported that liver adipogenesis and liver cancer lesion formation were significantly increased in ACACA (S79) (S212) knock‐in mice, and ACACA phosphorylation by AMPK was prevented.[23a] ACACA plays an important role in HCC,[23a] prostate cancer,[32] non‐small cell lung cancer,[23c] and breast cancer[33] by promoting adipogenesis. Here, ACACA is linked to hepatocellular carcinoma.