Notably, ACACA, as a key rate‐limiting enzyme in FA synthesis, is an important protein in FA metabolism and can catalyze acetyl‐CoA to form malonyl‐CoA.[24] The ACACA enzymatic activity (Figure 6G,H) and malonyl‐CoA content (Figure 6I,J) were decreased in the HCC cells with FASRL knockdown. Here, NQO1-DT is linked to hepatocellular carcinoma.