The small molecule drug ND‐654, which targets ACACA, was reported to mimic ACACA phosphorylation and inhibit tumor growth, revealing that ND‐654 can serve as a potential drug for the treatment of HCC.[23a] Additionally, ND‐646 can inhibit tumor growth by targeting ACACA in non‐small cell lung cancer.[23c] In contrast, this discovery may be a novel and easily controlled way to promote ACACA phosphorylation. This evidence concerns the gene ACACA and hepatocellular carcinoma.