FLT3 and acute myeloid leukemia: DROSHA has also been shown to localize within the cytoplasm to mediate the maturation of miR-155, a BIC-155 long noncoding (lnc) RNA-hosted oncogenic miRNA, in FLT3-ITD AML leukemic blasts, a MllPTD/wt/Flt3ITD/ITD mouse model, and MV4-11 cells [96].