Bone marrow mononuclear cells from primary AML patients showed the highest expression of METTL14 in MLL-r samples, METTL14 expression was induced by MLL-AF9 expression, and depletion led to apoptosis, leukemic cell differentiation, and a diminution of in vivo leukemogenesis using both shRNA and conditional genetic murine models [53]. This evidence concerns the gene KMT2A and acute myeloid leukemia.