Finally, we explored the relationship between LPCAT1 expression and drug sensitivity, and found that LPCAT1 can be used as a biomarker to predict the efficacy of some drugs, including 5-Fluorouracil, Gemcitabine, Mitomycin C, Sorafenib, Cabozantinib and Irinotecan in HCC. The gene discussed is LPCAT1; the disease is hepatocellular carcinoma.