FASN can use acetyl‐CoA as a substrate for lipid synthesis,[45, 46, 47] and enhanced histone acetylation levels at the FASN promoter region increase de novo lipid synthesis to promote tumor cell survival.[48] Because EBV‐miR‐BART18‐3p expression mediates nuclear acetyl‐CoA production (Figure 4K), we speculated that elevated LDHA may activate de novo lipogenesis through acetyl‐CoA‐mediated acetylation of histones in the FASN promoter region. This evidence concerns the gene LDHA and neoplasm.