HIF1A and colorectal carcinoma: Hypoxia regulated HIF‐1 at the level of protein stability by inhibiting its ubiquitin‐mediated degradation.[59] Under hypoxic conditions in cell culture, HIF‐1α mRNA did not change, but HIF‐1α protein levels increased.[60, 61, 62] However, our results were consistent with previous studies in that no changes in the mRNA level of HIF‐1α were observed.[59] But EBV‐miR‐BART18‐3p overexpression significantly increased HIF‐1α protein levels but not mRNA levels in hypoxic CRC cells.