LDHA and neoplasm: HIF‐1α facilitates tumor cell adaptation to the hypoxic microenvironment[36] and has been reported to activate LDHA expression by binding a hypoxia response element (HRE) within its promoter.[37] Thus, to determine whether a EBV‐miR‐BART18‐3p‐dependent increase in LDHA expression in CRC is mediated by HIF‐1α, we evaluated the mRNA expression levels of LDHA and HIF‐1α after EBV‐miR‐BART18‐3p overexpression and knockdown.