The results showed that SIRT1 overexpression reduced the LDHA mRNA levels in hypoxic DLD‐1 and SW480 cells (DLD‐1, P = 0.0135; SW480, P = 0.0081) (Figure S8, Supporting Information), thus indicating that SIRT1 may function as an intermediate between EBV‐miR‐BART18‐3p and HIF‐1α/LDHA in CRC. Here, LDHA is linked to colorectal carcinoma.