Ren et al. revealed that Wnt5a produced from the osteoblastic niche induced bone metastatic prostate tumour cell dormancy by activating the receptor tyrosine kinase-like orphan receptor 2 (ROR2)/SIAH2 signalling axis, resulting in repression of the Wnt/β-catenin pathway. Here, WNT5A is linked to prostate neoplasm.