LIF promoted breast cancer cell dormancy in the bone by binding to the LIF receptor (LIFR), which induced the expression of crucial dormancy-related genes in breast tumour cells, including thrombospondin-1 (TSP1), tropomyosin-1 (TPM1), TGFβ2, prolyl 4 hydroxylase α-1 (P4HA1), miRNA-190 (miR-190) and SELENBP1. The gene discussed is THBS1; the disease is breast carcinoma.