The largest subset (≈ 85%) of MG patients have autoantibodies that target the acetylcholine receptor (AChR), but a small subset of patients, who are negative for AChR autoantibodies, harbor autoantibodies that bind to muscle-specific tyrosine kinase (MuSK) [26], low-density lipoprotein receptor-related protein 4 (LRP4) [25, 50, 83] or agrin [83]. The gene discussed is LRP4; the disease is myasthenia gravis.