The patients with lower circulating osteocalcin concentrations exhibited higher insulin resistance and systemic inflammation (high-sensitivity C-reactive protein [hsCRP] and interleukin-6), adipokines (leptin and adiponectin), and ectopic body fat aggregation especially in young overweight and obese women [4, 7, 9, 21, 22]. The gene discussed is ADIPOQ; the disease is Insulin resistance.