CASP3 and neoplasm: Several studies highlighted the supportive effect through hedgehog signalling [61], miRNA 21 and 34a [62], and the Wnt signaling pathway [63].However, some studies have indicated the anti-tumor effects through suppression of angiogenesis [64], induction of cancer cell death by TRAIL (TNF-related apoptosis-inducing ligand) delivery [65] and down-regulating phosphorylation of Akt protein kinase and up-regulating cleaved caspase-3 [66].