TP53 and glioblastoma: Resveratrol has also been shown to enhance the chemosensitivity of glioblastoma-initiating cells to temozolomide by endorsing DNA double strand/ phospho-ataxia-telangiectasia mutated (ATM)/phospho-ATM- and Rad3-related (ATR)/p53 and suppressing STAT3 pathways [143, 144].