Carotenoids exhibit chemopreventive effects by suppressing the harmful effects of free radicals that regulate cancer cell proliferation, cell cycle progression, invasion, inflammation, and angiogenesis by regulating several molecular events including Akt/PI3K/mTOR, cyclin/cyclin-dependent kinase (CDK), PPAR, Wnt, VEGF, MMPs, and NF-κB signaling [207]. The gene discussed is VEGFA; the disease is cancer.