Additionally, γ-tocopherol was shown to induce a cytostatic effect on the cell cycle (G0/G1 arrest) in C-6 glioma cells by suppressing extracellular signal-regulated protein kinase 1/2 and protein kinase C (PKC) upstream and retinoblastoma phosphorylation downstream, leading to the suppression of cyclin E and cyclin-dependent kinase (CDK) 2/4 and activation of p27 [99]. The gene discussed is PRRT2; the disease is glioma.