Phloretin, an antioxidant flavonoid abundant in many plant species is known to arrest the cell cycle and induce apoptosis by counteracting metabolic reprogramming in human glioblastoma cells mediated through activation of p27, downregulation of PDKs and cyclins, and suppression of PI3K/AKT/mTOR signaling. The gene discussed is MTOR; the disease is glioblastoma.