A randomized comparison of reservoir-based polymer-free AES versus durable polymer everolimus eluting stents (EES) in patients with diabetes mellitus (RESERVOIR trial) which was a multicenter, prospective, open-label, assessor-blinded, active treatment-controlled, randomized clinical trial and involving 112 participants with diabetes mellitus, with 40% insulin-treated patients, suggested a higher efficacy of AES which might be more beneficial in patients with DM [18]. Here, INS is linked to diabetes mellitus.