To check the function of C9orf16 in cancer cell EMT, we examined the expression levels of CDH1 and VIM and found that C9orf16 deficiency dramatically increased the CDH1 mRNA levels but decreased VIM expression in PANC-1 cells, while C9orf16 overexpression significantly decreased CDH1 expression but increased the VIM mRNA levels (Fig. 6B-Fig. 6C). The gene discussed is CDH1; the disease is cancer.