CXCL6 and neoplasm: In addition, we also constructed hypoxic cell models in Herp3B and Huh7 cells to verify the expression of genes in the prognostic model and found that C7, CLEC1B, and CXCL6 were not only related to the tumor stemness but also related to hypoxia, suggesting that these three genes can serve as therapeutic targets for tumor stemness and hypoxia targeting.