CXCR4 and neoplasm: In addition, considering that CSCs were associated with tumor resistance, and hypoxia promoted CSCs metastasis and aggravates drug resistance, we compared the expression levels of various ICBs between the two groups and found that patients with lower risk ratings had greater levels of the genes PD-L1, CTLA4, CD4, CXCR4, IL6, LAG3, TGFB1, PD1, and PD-L2 than patients with higher risk scores.