Consistent with the results obtained from multi-omics data, IHC staining of VEGFR2 showed its higher expression in the SF1 lineage (GN and silent SF1) and NULL tumors than in other PitNETs (Kruskal-Wallis test, VEGFR2 H-score among TF lineages, P = 0.00012; VEGFR2 H-score among clinicopathological subtypes, P = 0.0021) (Supplementary information, Fig. S7g, h). This evidence concerns the gene KDR and ganglioneuroma.