We assessed the expression of the homeobox protein CDX2, which is a transcription factor responsible for the differentiation and maintenance of the intestinal phenotype16 and keratin 20 (CK20), whose expression is observed consistently higher in the well‐differentiated CRC tissue samples17 (Fig. 2c and Supplementary Fig. 1a). This evidence concerns the gene POU2F2 and colorectal carcinoma.