TGFB1 and diabetes mellitus: The key findings of our study include: (1) 1 month of diabetes is sufficient to observe enhanced tibia marrow adipogenesis in mice, (2) femurs may be more resistant to diabetes-mediated adipogenesis compared with tibiae, while both are susceptible to reduced osteogenesis, and (3) TGFB signaling pathway is suppressed in bone tissues of diabetic mice.