Potential targets for VitD anti-treatment osteoporosis and COVID-19 were enriched mainly in ErbB signaling pathway, MAPK signaling pathway, FoxO signaling pathway, endocrine resistance, and several pathways related to cancers (prostate cancer, bladder cancer, proteoglycans in cancer, pancreatic cancer, microRNAs in cancer, and breast cancer) (Table 2). The gene discussed is EGFR; the disease is osteoporosis.