As angiogenesis plays a pivotal role in cancer supply and metastasis, hAECs also inhibit angiogenesis in TME through inhibition of heat shock protein-90 (HSP-90) and secretion of anti-angiogenic factors including thrombospondin, tissue inhibitors of matrix metalloproteinase (TIMP) -1, -2, -3, and -4, IL-10, collagen XVIII, endostatin, pigment epithelium-derived factor (PEDF) and IL-1 receptor antagonist21. This evidence concerns the gene SERPINF1 and cancer.