In CD71+Ter119– stage, the change in transcriptome under Mettl16 deficiency was modest, and most of the differentially regulated genes were associated with the hypoxic response, which was attributable to severe anemia in Mettl16fl/flEpor-Cre+ mice (Supplementary Fig. 4d and Supplementary Data 2). This evidence concerns the gene METTL16 and anemia (phenotype).