Our data suggest that LRRFIP2-variant 2 generated by exon7 deletion inhibits recruitment of CARM1 in combination with ACTR, one of p160 family of coactivators onto the SERPINE1 promoter, leading to decreased expression of SERPINE1. Taken together, our results indicate that LRRFIP2 variant 2 suppresses the metastatic phenotype of gastric cancer by inhibiting the oncogenic function of CARM1. Here, CARM1 is linked to gastric cancer.