Interestingly, LRRFIP2 variant 3 was shown to bind LRRFIP2 variant 2 and inhibit the binding of LRRFIP2 variant 2 to CARM1 (Supplementary Fig. 18), suggesting that LRRFIP2 variant 3 suppresses tumor suppressor activity of LRRFIP2 variant 2 by blocking the interaction between CARM1 and LRRFIP2 variant 2. This evidence concerns the gene CARM1 and neoplasm.