A series of bio-functional experiments revealed that DUSP5P1 significantly promoted cell migration/invasion abilities in vitro, and lung, liver, and peritoneal metastasis of GC cells in nude mice in vivo; whilst depletion of DUSP5P1 by shRNA in MKN45 cells inhibited lung and liver metastasis in vivo. This evidence concerns the gene DUSP5P1 and gastric cancer.