Studies based on anatomical landmarks have shown that bvFTD is associated with decreased FC in the frontal, temporal and parietal lobes (Filippi et al., 2017; Reyes et al., 2018); lower regional homogeneity in the dorsolateral prefrontal cortex (DLPFC) (Farb et al., 2013); loss of negative correlation (anticorrelation) between the DLPFC and the ventromedial prefrontal cortex (Farb et al., 2013); reduced RSFC in the sensorimotor network (Lee et al., 2014; Trojsi et al., 2015); and increased RSFC in the cerebellum of GRN mutation carriers with FTD (Premi et al., 2014). The gene discussed is GRN; the disease is frontotemporal dementia.