Both ingenuity enrichment analysis (IPA) and STRING pathway analysis revealed key known features involved in SLE pathogenesis being significantly deregulated in SLE B cells compared to HC, such as complement activation, circulating antibodies regulation, cytokine production (IL-1, IL-4, IL-6, and IL-10), antigen presentation, inflammatory response, nuclear factor κB (NF-κΒ) activation, and mammalian target of rapamycin (mTOR) signaling (Fig. 1C, fig. This evidence concerns the gene IL6 and systemic lupus erythematosus.