While our data highlight a clear increase in ATR/Chk1 pathway activation, with no alterations in ATM/Chk2 and DNA-PKcs in SLE B cells, a study by Taher et al. (45) reported a reduction in ATR activation and an increase in ATM activation in B cells from patients with SLE. This evidence concerns the gene CHEK2 and systemic lupus erythematosus.