Combined with the regulatory relationship between miR-27b-3 and FBLN5 and the adsorption relationship between LINC01089 and miR-27b-3p, these results suggested that LINC01089 upregulates the expression of FBLN5 by adsorbing miR-27b-3p and exerts a tumor suppressor function in thyroid cancer. The gene discussed is FBLN5; the disease is thyroid cancer.