Endothelin 1 (ET-1) (Lerman et al. 1991; Donato et al. 2009) and nuclear factor κB (NFκB) (Cominacini et al. 2005; Real et al. 2010; Silver et al. 2007; Donato et al. 2007) were elevated in CAD patients and/or subjects with an atherosclerotic-prone phenotype. This evidence concerns the gene EDN1 and coronary artery disorder.