For example, CD103+ DCs seem indeed to play an important role in pulmonary tolerance, since they are able to induce Treg cell generation in ovalbumin-challenged mice [241, 242], while their absence has been linked with exacerbated AAI and eosinophilia in both ovalbumin- and HDM-induced asthma [241–243]. This evidence concerns the gene ITGAE and Increased total eosinophil count.