GBF1 and poliovirus infection: In the case of poliovirus infection, 3A redistributes GBF1 to viral replication complexes during early stages of replication and subverts its guanine nucleotide exchange factor (GEF) function in infected cells (Belov et al., 2007, 2008; Richards et al., 2014), suggesting that poliovirus protein 3A may attenuate GBF1’s normal function creating a vi-hypomorph, rendering cells susceptible to disruption of proteins synthetically lethal with GBF1.