Ets1, Sp1 and Src all regulate cell progression in colorectal cancer [30–34] , and additionally, both Ets1 and Src are highly expressed in colorectal cancer [10,33,34] , implying that there may be reciprocal links between Ets1, Sp1 and Src in the development of colorectal cancer. Here, ETS1 is linked to colorectal cancer.