CD8A and neoplasm: As for tumor immune activation, unlike GMS-high group we noticed that GMS-low group showed higher IFN-γ signaling score (KEYNOTE012, P=0.041; POPLAR, P=0.021), ICR score (P=0.036), inflammation signature score (P=0.020), APM score (P=0.015), and CD8+T-effector score (P=0.013) (Figure 5F).