We observed higher expression levels of susceptibility gene MTAP in osteocytes and relatively lower expression levels in CAFs and several immune sub‐clusters, including mast cells, OCs, proliferating TAMs and CD4+ T cells (Figure 7A); however, MTAP was not associated with prognosis of osteosarcoma patients (Figure 7B). The gene discussed is MTAP; the disease is osteosarcoma.