Interestingly, B cells in TNF‐Tg SBM also show increased levels of C‐type lectin domain family gene CLEC4D and CLEC4E, suggesting that the CLEC11A+ B cells in osteosarcoma may have similar biological functions as the TNF‐Tg SBM‐derived B cells.64 Here, CLEC4D is linked to osteosarcoma.