In this study, we found that another combination agents HCPT and CRI showed synergistic activity on the same lung cancer cell lines including H460 (KRAS, large cell lung cancer), H1975 (L858R/T790M+, lung adenocarcinoma), and HCC827 (E746-A759del/T790M-, lung adenocarcinoma) cells. Here, KRAS is linked to lung large cell carcinoma.