Various driver gene mutations of NSCLC were identified nearly two decades such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), V-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), C-ros oncogene 1 (ROS1), cellular mesenchymal-to-epithelial transition (c-Met), and so on.4 The gene discussed is ROS1; the disease is non-small cell lung carcinoma.